SLU-PP-332: The "Exercise Pill"
SLU-PP-332 is an experimental compound that activates all three estrogen-related receptors (ERRα, ERRβ, and ERRγ) to mimic exercise at the cellular level… 12% body weight loss in four weeks with no diet changes and a 50% increase in running capacity. No human trials have begun… realistic availability is 8-13 years away.
Quick Facts
| QUICK FACTS | DETAILS |
|---|---|
| Compound Type | Pan-ERR agonist (exercise mimetic) |
| Targets | ERRα, ERRβ, ERRγ (estrogen-related receptors) |
| Key Effects (Mice) | 12% weight loss, 50% endurance increase, improved metabolic markers |
| Administration | Injection (research settings) |
| Human Trials | None started |
| Regulatory Status | Research compound only; not approved anywhere |
| Estimated Timeline to Availability | 8-13 years (if development proceeds) |
| Risk Level for Self-Experimentation | Very High (no human safety data exists) |
What Is SLU-PP-332 and Why Does It Matter?
- Developed at Washington University in St. Louis.
- Dr. Bahaa Elgendy is named as a developer.
- Class: pan-ERR agonist (ERRα/β/γ) / exercise mimetic, nicknamed "the exercise pill".
What Do the Mouse Studies Show?
- 12% weight loss in mice.
- 50% increase in endurance/running capacity.
- Improved metabolic markers.
Is SLU-PP-332 Safe?
In mice, no toxicity was observed at 50 mg/kg twice daily for 10 days.
A strong gray-market warning is given: do not self-experiment with it.
- Long-term effects unknown.
- Human toxicity unknown.
- Cardiovascular effects unknown (ERRα in the heart).
- Cancer risk unknown.
- Hormonal effects unknown.
- Reproductive effects unknown.
- Drug interactions unknown.
- Cognitive effects unknown.
Dosing
No human dosing exists; use is research-only and by injection.
How Far Away Is Availability?
Estimated timeline to availability is 8-13 years if development proceeds. Development stage runs from Discovery (done) to Approval (8-13 years).
How Does It Compare to Other Exercise Mimetics?
- The source compares SLU-PP-332 against these other exercise mimetics: AICAR, GW501516 (Cardarine), Compound 14, MOTS-c, and Irisin.
- 01ERR agonist overview — https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/estrogen-related-receptor
- 02Kidney markers — https://www.jrenendo.com/PDF/jre-10-e25143.pdf
- 03"A Synthetic ERRα Agonist…" — https://www.biorxiv.org/content/10.1101/2022.10.05.510974v1.full
- 04"Synthetic ERRα/β/γ Agonist…" — https://pubmed.ncbi.nlm.nih.gov/36988910/
This profile is being expanded — additional sections from the source are still being added.